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Fibrosis drug Product List

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Tohoku University Technology: Pharmaceutical Composition for the Prevention or Treatment of Fibrosis: T10-134

Suppress the onset and progression of pulmonary fibrosis!!

Pulmonary fibrosis is a disease in which the lungs become fibrotic, shrink, and lose function, leading to inadequate gas exchange. As pulmonary fibrosis progresses, it ultimately results in respiratory distress and can be fatal. There are currently no effective drugs or treatments established for this disease, and the survival period for affected patients is said to be 2 to 3 years. The inventor of this invention has discovered that stanniocalcin 1 (STC1), a hormone in the body, has an inhibitory effect on the onset and progression of pulmonary fibrosis. STC1 is thought to exhibit anti-fibrotic effects by reducing endoplasmic reticulum stress, which is one of the causes of fibrosis, and the associated production of TGF-β1.

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Tohoku University Technology: Organ Fibrosis Inhibitor: T13-204

Confirmed the effects of fibrosis and inflammation improvement in a kidney fibrosis model mouse!

When the kidneys are damaged for some reason, it is known that inflammation and fibrosis can occur. As symptoms progress, renal failure can develop, necessitating regular dialysis. Dialysis is a significant burden for patients, and there is a desire for the development of therapeutic drugs that can delay the initiation of dialysis. The inventors of this invention have discovered compounds with anti-inflammatory and anti-fibrotic effects. The group of compounds in this invention is expected to be useful as fibrosis inhibitors.

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